Phytochemical Analysis published by John Wiley & Sons Ltd. Symphytum officinale L high-resolution mass spectrometry phenolic markers pyrrolizidine alkaloids rosmarinic acid. officinale, revealing not only numerous toxic PAs, but also a significant number of valuable phenolic compounds that could contribute to the bioactivities of comfrey-based preparations. This study brings new insights into the phytochemical complexity of S. In addition, the quantitative analyses revealed that globoidnan B, rabdosiin and globoidnan A are new phenolic markers that can be used together with rosmarinic acid and PAs for the quality control of commercial comfrey root batches. caffeic and rosmarinic acids, rabdosiin, globoidnan A, globoidnan B) and 9 nonphenolic compounds (sugars, organic and fatty acids) were fully or partly annotated in the analysed samples. However, the hybrid differs in that it has a corolla 1316 mm long, purple or pink flower buds, a calyx 57 mm long, and short, broad papillae on the margins of the fornices (vs. asperum in that the leaves are not decurrent on the stem (or infrequently shortly decurrent for a distance of less than 10 mm). intermedine, lycopsamine, acetylintermedine, acetyllycopsamine, symphytine, symphytine-N-oxide), 17 phenolic compounds (i.e. Symphytum asperum × Symphytum officinale Symphytum ×uplandicum Nyman is a very rare comfrey hybrid in New England known from CT, VT. Liquid chromatography hyphenated with high-resolution tandem mass spectrometry (LC-HRMS/MS) was used for the profiling of PAs and phenolic compounds, whereas LC-MS/MS and liquid chromatography with diode array detection (LC-DAD) were used for their quantification.Ģ0 PAs (i.e. The aim of this study was to perform the qualitative and quantitative analysis of pyrrolizidine alkaloids (PAs) and phenolic compounds in the hydroethanolic extracts of 16 commercial comfrey root batches purchased from 12 different European countries. A wide range of topical preparations and dried roots for ex tempore applications are marketed in European drug stores or pharmacies. (comfrey, Boraginaceae) is a cultivated or spontaneously growing medicinal plant that is traditionally used for the treatment of bone fractures, hematomas, muscle pains and joint pains.
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